Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide

摘要

Cu(II) complexes of 1-[4-(3-ethyl-piperidine-2,6-dione)-3-yl]-phenyl-2,4,6-trisubstitutedpyridinium perchlorates, containing alkyl, aryl and combinations of these two types of moieties in theirmolecule were synthesized and characterized by elemental analysis, spectroscopy, magnetic,thermogravimetric and conductimetric measurements. In these complexes, Cu(II) ions are in octahedralgeometry with four water molecules occupying the equatorial coordination sites and the two organic ligandsin deprotonated state the remaining axial ones. The donor atom of these ligands is constituted by the ionizednitrogen of the glutarimide moiety. The new derivatives possess weak inhibitory activity towards the zincenzyme carbonic anhydrase.